无先兆型偏头痛患者间歇期脑血流检测

TCD,CBA AND BRAIN MRI STUDY IN MIGRAINEURS DURING THE HEADACHEFREE PERIOD

摘要:

采用经颅多普勒超声（ＴＣＤ），脑血管血液动力学分析仪（ＣＢＡ）和磁共振成像（ＭＲＩ）等多种先进检查手段对无先兆型偏头痛患者头痛间歇期进行检测。４０例患者进行了ＴＣＤ检查，结果示患者组双侧大脑中动脉平均血流速度增高，有９例患者颅内动脉平均流速不对称。４４例患者的ＣＢＡ检查显示，患者组脑血管外周阻力Ｒｖ，动态阻力ＤＲ和临界压力ＣＰ增高。这些结果提示患者间歇期颅内血管紧张性增高，血流状态仍呈现不稳定性，推测其发病机理以血管因素为主。另外，有１０例患者进行头颅ＭＲＩ检查，６例结果异常，其中５例是颅内多发性缺血灶，１例是腔隙性梗塞。这是否由于长期血管功能异常导致的形态学变化，尚待进一步研究。

Abstract:

Transcranial Doppler Sonography(TCD),Cerebrovascular Hemodynamics Analyzer(CBA)and Magnetic Resonance Imaging(MRI)were performed in migraine patientswithout aura during the headache-flee period.TCD examination in 40 patients showed significantly elevated mean flow velocities in bilateral middle cerebral arteries,and markedasymmetry of MFV mean flow velocity in corresponding intracranial arteries was found in 9patients.The results of CBA in 44 Patients revealed elevations of cerebral vascular resistance,dynamic resiStance and critical pressure.Taken together,these results suggest intracranial vasotonus and instable vascular tone of migraineurs without aura in the interictalperiod.Besides,MRI of the brain in 6 out of 10 patients showed multiple ischemic lesions orlacunar infarction.It is to be determined in the future whether these morphological changesare due to long-term vascular abnormality in migraine P8tients.