神经源性疼痛的动物模型

ANIMAL MODELS OF NEUROPATHIC PAIN

摘要:

神经源性疼痛的发病机理尚不完全清楚，虽有多种治疗方法蛤效果都不甚满意。为了探索神经源性疼痛的发病机理及检验新的治疗方法，基础研究者发展了一些神经源性疼痛的动物模型，这些研究模型的建立使人们可以应用在临床研究中不能采用的实验手段进行研究。但这些动物模型的价值则取决于它们与人类神经源性疼痛的痛觉症状及感觉变化上的相似程度。本文先介绍神经源性动物模型的感觉异常（痛觉过敏和痛觉超敏）及其检测，再介绍一外周

Abstract:

Animal models of neuropathic pain have been developed in order to replicate syndromes afflicting humans.The two major golas of this area of research are to explore and identify the underlying mechanisms of human neuropathic pain and to develop better and more specific therapies. Animal models of neuropathic pain are mainly produced by inflicting injury involving somatosensory pathway in animal of various species and by then observing behavioral signs which suggest the existence of spontaneous pain and abnormal evoked pains(allodynia and hyperalgesia) in these animals.The anatomical, biochemical and functonal consequences of such nerve injury can be subsequently analysed to elucidate the mechanism of the associated behavioral changes. The preslent review intends to summarize several animal models of neuropathic pain after injury to both peripheral and central nervous systems with regard to their engendering, sensory symptoms and drawbacks.