Abstract:A total of 102 cases of the patients with pain in knee joint caused by infrapatellar fat pad lesion was reported.Fat pad lysis and silver needle therapy were used for treatment.The rate of excellent and good result was 90.2%.According to the feature of the fat pad anatomy and biomechanics of knee joint,the authors considered aseptic inflammatory lesion of the fat pad attached to patellar tip as the important pathogenic elements for induction of chronic pain in knee joint.Silver needle therapy and surgical fat pad lysis can remove the aseptic inflammatory stimulation in the lesion area,thereby to relieve chronic pain in knee Joint.